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KMID : 1134820140430030367
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Journal of the Korean Society of Food Science and Nutrition
2014 Volume.43 No. 3 p.367 ~ p.373
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Anticancer Activity of Methyl Gallate in RC-58T/h/SA#4 Primary Human Prostate Cancer Cells
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Kwon Soon-Jae
Lee Ju-Hye
Kim Jae-Yong
Moon Kwang-Deog
Lee Sung-Tae
Seo Kwon-Il
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Abstract
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In this study, we investigated the anticancer activity of methyl gallate (MG), which is the major biologically active component of Galla Rhois, in RC-58T/h/SA#4 human prostate cancer cells. MG inhibited cell proliferation in a dose-dependent manner. Cell death induced by MG increased the population of cells in sub-G1 phase, formation of apoptotic bodies, nuclear condensation, and DNA fragmentation. Apoptosis induced by MG was associated with activation of initiator caspases-8 and -9 as well as effector caspase-3. Endocrine disruptors such as dioxin and bisphenol A increased growth of RC-58T/h/SA#4 cells in charcoal-treated FBS (cFBS) medium. Cell proliferation was highest upon treatment with 1 nM and 0.1 μM dioxin and bisphenol A, respectively. MG also dose-dependently inhibited cell proliferation in RC-58T/h/SA#4 cells treated with endocrine disruptors. These results indicate that MG exerts anticancer effects on RC-58T/h/SA#4 primary human prostate cancer cells.
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KEYWORD
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methyl gallate, anticancer activity, apoptosis, environmental hormone
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